Royal Air Force Typhoon FGR4s have conducted a mission with France's air force in a coordinated attack against an hidden munitions depot in Syria employed by the IS group, according to the British defence ministry.
The location, identified by intelligence, was assessed as storing arms and explosives, the statement said, and was situated in mountainous terrain just above the ancient city of Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to target a number of entry passages down to the depot... early reports are that the objective was successfully hit," the ministry announced.
There was no sign of any civilian impact in the strike conducted Saturday night and all the aircraft returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as ISIS - enforced extremist governance over large swathes of Iraq and Syria until 2019.
"This action shows the UK's leading role, and determination to operate in unison with our partners, to eradicate any re-emergence of Daesh and their violent and radical beliefs in the area," UK Defence Secretary the minister said.
RAF aircraft have carried out surveillance missions over Syrian airspace to "deter any attempted comeback" of IS after its military defeat at the battle of Baghuz in the year 2019, the authorities noted.
"I want to thank the personnel of British forces who took part in this operation for their expertise and their valour," he said. "Including them were numerous UK service members stationed over the holidays. This action, to eliminate militants who threaten our safety, shows how British military are ready to step up, throughout the year, ensuring Britain's security within its borders and powerful internationally."
During December, the US military conducted what it termed a "massive strike" on Daesh sites in the country, subsequent to an attack claimed the lives of two American soldiers and a civilian linguist in the Palmyra area.
The U.N. says IS still boasts between 5,000 and 7,000 militants in Iraq and Syria.